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KMID : 0389420090170040435
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Korean Journal of Stress Research
2009 Volume.17 No. 4 p.435 ~ p.440
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Panax ginseng Attenuates MK-801-Induced Stereotypy in Mice
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Chung Joo-Ho
Cha Seon-Woo
Kim Su-Kang
Kang Sung-Wook
Kim Young-Ock
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Abstract
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Schizophrenia is a mental disorder with lifetime prevalence on approximately 1% of the general population. After MK-801 (NMDA receptor antagonist) treatment, stereotyped behavior in mice is significantly increased, and therefore this is widely used as an animal model for the study of the pathophysiology of schizophrenia. Ginseng, the root of Panax ginseng, is known as a representative tonic for over 2,000 years in East countries such as China, Japan, and Korea. The objective of this study was to investigate the effect of ginseng on stereotyped behavior in MK-801-induced mice. We evaluated the stereotypy score in mice after single and repeated administration of MK-801 to examine acute and chronic responses. A total of 80 male mice were used for the acute and chronic session tests. Each session test was divided into 4 groups (10 mice/group), which were treated with saline (Control group), 400 mg/kg ginseng (Control＋Ginseng group), 0.6 mg/kg MK-801 (MK801 group), and 0.6 mg/kg MK-801 and 400 mg/kg ginseng (MK801＋Ginseng group), respectively. For the acute session test, mice were injected with a single dose of MK-801 (0.6 mg/kg, i.p). For the chronic session test, mice were daily injected with MK-801 for consecutive 7 days. Ginseng (400 mg/kg, p.o) was administered 30 min before the MK-801 treatment. The results showed that stereotypy score was increased in the MK801 group of both the acute and chronic session tests, compared with the Control group. Ginseng reduced the score of MK-induced stereotypy in the chronic session test, but not in the acute session test. The present results might be related to the long-term effect of ginseng in treating the symptoms of schizophrenia, including stereotyped behavior.
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KEYWORD
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Schizophrenia, Ginseng, MK-801, Stereotypy
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